Basic Information
| LncRNA/CircRNA Name | DACOR1 |
| Synonyms | DACOR1, LP2570, TCONS_00023265 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | RNA-seq, qPCR, Western blot, RIP, ChIP etc. |
| Sample | colon cancer tissues, cell line (HCT116) |
| Expression Pattern | down-regulated |
| Function Description | DACOR1 shows high, tissue-specific expression in the normal colon but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Induction of DACOR1 led to the activation of tumor-suppressor pathways and attenuation of cancer-associated metabolic pathways. |
| Pubmed ID | 26307088 |
| Year | 2015 |
| Title | DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer. |
External Links
| Links for DACOR1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |