Basic Information
| LncRNA/CircRNA Name | DACOR1 |
| Synonyms | DACOR1, LP2570, TCONS_00023265 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | colon cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | In the current study, we assessed the impact of a key DNMT1-associated lncRNA, DACOR1, on genome-wide DNA methylation using reduced representation bisulfite sequencing (RRBS). Our findings demonstrated that induction of DACOR1 in colon cancer cells restores DNA methylation at thousands of CpG sites throughout the genome including promoters, gene bodies, and intergenic regions. Importantly, these sites overlap with regions of the genome that become hypomethylated in colon tumors. Furthermore, induction of DACOR1 results in repression of FOS and JUN and, consequently, reduced AP-1 transcription factor activity. |
| Pubmed ID | 30348202 |
| Year | 2018 |
| Title | The DNMT1-associated lincRNA DACOR1 Reprograms Genome-Wide DNA Methylation in Colon Cancer |
External Links
| Links for DACOR1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |