Basic Information
| LncRNA/CircRNA Name | CYTOR |
| Synonyms | NA |
| Region | GRCh38_2:87454781-87636740 |
| Ensemble | ENSG00000222041 |
| Refseq | NR_024204 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR etc. |
| Sample | CRC tumorS and matched adjacent nontumor tissues ,The normal human colon epithelial cell line human fetal normal colonic mucosa cell (FHC) and the CRC human cell lines (Caco2, RKO, HT29, HCT116, LOVO, SW480, and SW620) |
| Expression Pattern | up-regulated |
| Function Description | The expression of CYTOR was significantly elevated in CRC tumor tissues and cell lines.Aberrant expression of CYTOR was significantly related to TNM stage, T stage, N stage, and perineural and venous invasions.High-CYTOR expression was associated with poor overall survival in CRC patients ,and high-CYTOR expression was an independent prognostic factor, which led to poor OS.There were 18 microRNAs (miRNAs) interacted with CYTOR, and one of them, miR-3679-5p might collaborate with metastasis-associated in colon cancer-1 (MACC1).Pearson correlation analysis showed a significant positive correlation between the expression levels of CYTOR and MACC1. In conclusion, lncRNA-CYTOR played an important role in tumorigenesis and development through the CYTOR/miR-3679-5p/MACC1 axis. |
| Pubmed ID | 31144988 |
| Year | 2019 |
| Title | lncRNA-CYTOR?Works as an Oncogene Through the?CYTOR/miR-3679-5p/?MACC1?Axis in Colorectal Cancer |
External Links
| Links for CYTOR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |