Basic Information
| LncRNA/CircRNA Name | CTNNAP1 |
| Synonyms | CTNNA1P1, CTNNAP1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Cell transfection, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (SW480 and SW620) |
| Expression Pattern | down-regulated |
| Function Description | The result showed that the expression of CTNNAP1 was downregulated in 70% tumor samples (39/56) compared to adjacent normal samples. The mechanistic experiments revealed that pseudogene CTNNAP1 played a pivotal role in the regulation of its cognate gene CTNNA1 by competition for microRNA-141. Moreover, gain-of-function approaches showed that overexpression of CTNNAP1 or CTNNA1 significantly inhibited cell proliferation and tumor growth in vitro and in vivo by inducing G0/G1 cell cycle arrest. |
| Pubmed ID | 27487124 |
| Year | 2016 |
| Title | Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression. |
External Links
| Links for CTNNAP1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |