Basic Information
| LncRNA/CircRNA Name | ADPGK-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:72782835-72798199 |
| Ensemble | ENSG00000260898 |
| Refseq | NR_040107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay etc |
| Sample | CRC tissues,cell lines((HCT116, HT29, SW480, and LoVo)) |
| Expression Pattern | up-regulated |
| Function Description | ADPGK-AS1 was upregulated in CRC tissues and cells. Knockdown of ADPGK-AS1 attenuated the proliferative, migratory, and invasive abilities of CRC cells. Meanwhile, miR-525 was confirmed to be the target of ADPGK-AS1 and FUT1 was the downstream gene binding miR-525. The regulatory loop ADPGK-AS1/miR-525/FUT1 was found to aggravate the malignant progression of CRC. |
| Pubmed ID | 32196589 |
| Year | 2020 |
| Title | ADPGK-AS1 Promotes the Progression of Colorectal Cancer via Sponging miR-525 to Upregulate FUT1 |
External Links
| Links for ADPGK-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |