Basic Information
| LncRNA/CircRNA Name | LNC CRYBG3 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | cell lines (A549, H1299) |
| Expression Pattern | up-regulated |
| Function Description | We recognized a lncRNA, LNC CRYBG3, which can interact with lactate dehydrogenase A (LDHA), a vital enzyme of glycolysis, is highly upregulated in both clinical lung cancer tissues and in vitro cultured lung cancer cell lines. the knockdown of LNC CRYBG3 led to opposite results and suppressed cell proliferation. Based on the TCGA database, lung cancer patients with a high LDHA expression level showed a lower survival percentage than those with a low LDHA expression. |
| Pubmed ID | 30026857 |
| Year | 2018 |
| Title | Long Non-Coding RNA CRYBG3 Regulates Glycolysis of Lung Cancer Cells by Interacting With Lactate Dehydrogenase A. |
External Links
| Links for LNC CRYBG3 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |