Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, FISH, MTT assay etc. |
| Sample | CRC tissues, cell lines (HCT116 and SW480) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of the CRNDE were upregulated in CRC clinical tissue samples. Significantly, we found that the repression of cell proliferation, the reduction of chemoresistance, and the inhibition of Wnt/B-catenin signaling induced by CRNDE knockdown would require the increased expression of miR-181a-5p. |
| Pubmed ID | 28086904 |
| Year | 2017 |
| Title | The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/B-catenin signaling. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |