Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Dual luciferase reporter assay etc. |
| Sample | HCC tissues, cell lines (MHCC97H, Hep3B, MHCC97L, BEL-7402, QGY-7703, HCCC9810, and HuH7) |
| Expression Pattern | up-regulated |
| Function Description | Herein, we found that the expression of CRNDE was increased in human hepatic carcinoma (HCC) tissues and cell lines. At the same time, CRNDE promotes HCC cell proliferation, migration, and invasion in vitro. Quantitative real-time polymerase chain reaction (PCR) demonstrated that miR-384 was significantly downregulated in HCC tissues. Moreover, we indicated CRNDE negatively regulated miR-384 expression in HCC. |
| Pubmed ID | 27822419 |
| Year | 2016 |
| Title | LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |