Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | gastric cancer tissue, cell lines (MGC-803, MNK-45, SGC-7901, HGC-27, GES) |
| Expression Pattern | up-regulated |
| Function Description | expression of CRNDE was higher in GC tissues and cells compared with the normal gastric tissue and normal gastric cell lines. High expression of CRNDE was correlated with invasion depth , TNM stage and lymph node metastasis. Furthermore, high CRNDE expression was associated with shorter overall survival of GC patients. high CRNDE expression was a significant independent predictor of poor survival in GC.knockdown of CRNDE inhibited cell proliferation, migration and invasion of GC.CRNDE exerted its oncogenic role by affecting PI3K/AKT signaling pathways. |
| Pubmed ID | 29243780 |
| Year | 2017 |
| Title | Long non-coding RNA CRNDE is a novel tumor promoter by modulating PI3K/AKT signal pathways in human gastric cancer. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |