Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, CCK-8 assay, in vitro knockdown etc. |
| Sample | hepatoblastoma tissues, cell lines (HepG2, HuH-6, SMMC-7221, QSG-7701 and L01) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE is significantly up-regulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. CRNDE knockdown reduces tumor growth and tumor angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, and angiogenic effect in vitro. Mechanistic studies show that CRNDE knockdown plays its anti-proliferation and anti-angiogenesis role via regulating mammalian target of rapamycin (mTOR) signaling. |
| Pubmed ID | 28178668 |
| Year | 2017 |
| Title | Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for hepatoblastoma | OMIM COSMIC |