Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR, RNAi, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | MM tissues, cell lines (MM1.S, NCIH929, U266, RPMI8226) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE expression level, in MM sample and cell lines, is higher than control. Knockdown of CRNDE significantly inhibits the proliferative vitality of MM cells and induces cell cycle arrest in G0/G1 phase and apoptosis-promoting. Subsequently, miR-451 inhibitor rescues the tumorigenesis inhibition induced by CRNDE knockdown. |
| Pubmed ID | 28276319 |
| Year | 2017 |
| Title | Long Non-coding RNA CRNDE Promotes Multiple Myeloma Cell Growth By Suppressing MiR-451. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |