Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell lines (5637,T24), BC tissues |
| Expression Pattern | up-regulated |
| Function Description | CRNDE was significantly increased in bladder cancer, and overexpressed expression of CRNDE was positively related with advanced TNM stage of bladder cancer patients. In addition, in vitro experiments showed that CRNDE strengthened cell migration/proliferation and inhibited cell apoptosis in bladder cancer.CRNDE can suppress E2F3 expression to increase miR-145 expression. |
| Pubmed ID | 29710461 |
| Year | 2018 |
| Title | Overexpression of CRNDE promotes the progression of bladder cancer. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |