Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, other |
| Sample | HCC tissues and cell liness (HepG2, SMMC7721, SK-hep1,and Huh7) |
| Expression Pattern | up-regulated |
| Function Description | In vitro, we revealed that knockdown of CRNDE inhibited cell proliferation, migration, and cell invasion capacities in HCC. Animal studies indicated that CRNDE knockdown represses both growth and metastasis of HCC tumors in vivo. Moreover, knockdown of CRNDE suppressed the cell epithelial-mesenchymal transition (EMT) process by increasing the expression of E-cadherin and ZO-1, whereas, decreasing the expression of N-cadherin, slug, twist, and vimentin in HCC cells. We also revealed that knockdown of CRNDE suppressed the Wnt/?-catenin signaling in HCC. Thus, CRNDE could modulate EMT of HCC cells and knockdown of CRNDE impaired the mesenchymal properties |
| Pubmed ID | 30430650 |
| Year | 2018 |
| Title | LncRNA CRNDE Promotes the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via Enhancing the Wnt/?-catenin Signaling Pathway |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |