Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | NA |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | cervical cancer and adjacent normal tissues ,human cervical epithelial cells (CC-H059 cells) ,cervical cancer cell lines (HCC94, C-33 A, MS751, Siha, Caski and C4-1 cells) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE, miR-183 and CCNB1 were in the same network path. Their expressions were up-regulated in CC tissues and cells.Silencing CRNDE-inhibited cell proliferation, migration and invasion, restricted solid tumor growth and promoted cell apoptosis. Moreover, miR-183 targeted the CCNB1 3'UTR and regulated its expression.Additionally, CRNDE could positively regulate CCNB1 expression by sponging miR-183. |
| Pubmed ID | 31605132 |
| Year | 2019 |
| Title | LncRNA CRNDE Acts as an Oncogene in Cervical Cancer Through Sponging miR-183 to Regulate CCNB1 Expression |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |