Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | Colorectal neoplasia differentially expressed |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot analysis |
| Sample | normal osteoblast cells hFOB1.19 and the OS cell lines U2OS, MG63, and MNNG/HOS,OS tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression of CRNDE was high in OS tissues and cell lines, and partly induced by SP1. CRNDE knockdown attenuated OS cell proliferation and invasion and induced apoptosis and G0/G1 arrest. Moreover, the expression of mesenchymal markers N-cadherin, Vimentin and Snail were downregulated, while the expression of epithelial markers E-cadherin and ZO-1 were conversely upregulated due to CRNDE knockdown. The mechanistic investigations showed that CRNDE promoted glycogen synthase kinase-3? phosphorylation to activate the Wnt/?-catenin pathway. |
| Pubmed ID | 31898343 |
| Year | 2020 |
| Title | LncRNA CRNDE Is Activated by SP1 and Promotes Osteosarcoma Proliferation, Invasion, and Epithelial-Mesenchymal Transition via Wnt/?-catenin Signaling Pathway |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |