Basic Information
| LncRNA/CircRNA Name | CR749391 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR, Western blot, RIP, luciferase activity assay |
| Sample | GC samples,GC BGC-823, SGC-7901, and MGC-803 cell lines, normal gastric epithelial GES-1 cells, and 293 cells |
| Expression Pattern | down-regulated |
| Function Description | CR749391 was observed to be downregulated in GC compared with that of normal gastric cell lines.CR749391 depletion in normal gastric epithelial cells promoted cell viability, migration and invasion, and conferred resistance to apoptosis, whereas ectopic CR749391 overexpression had the opposite effect in GC cells and inhibited in vivo tumor growth. |
| Pubmed ID | 31853323 |
| Year | 2020 |
| Title | LncRNA CR749391 Acts as a Tumor Suppressor to Upregulate KLF6 Expression via Interacting With miR-181a in Gastric Cancer |
External Links
| Links for CR749391 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |