Basic Information
| LncRNA/CircRNA Name | CR593775 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, Western blot etc. |
| Sample | cell lines (MCF-7 and T-47D) |
| Expression Pattern | up-regulated |
| Function Description | From these 127 DE lncRNAs, we selected the top 25 most significant genes for further validation and analysis (electronic supplementary material, table S2). For 23 out of 25 (92%) of the lncRNAs tested, quantitative real-time PCR (qRTPCR) on cDNA templates confirmed the microarray results. These results suggest that CR593775 is involved in mediating the downstream effects of oestrogen signalling on breast cancer cell proliferation, including possible interactions with mechanisms of DNA synthesis regulation. Cell cycle analysis in synchronized cells indicates that disruption of CR593775 expression did not affect cell cycle progression. |
| Pubmed ID | 28003470 |
| Year | 2016 |
| Title | Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells. |
External Links
| Links for CR593775 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |