Basic Information
| LncRNA/CircRNA Name | CPS1-IT1 |
| Synonyms | CPS1-IT1, CPS1-IT, CPS1IT, CPS1IT1, PRO0132 |
| Region | GRCh38_2:210617571-210619876 |
| Ensemble | ENSG00000280837 |
| Refseq | NR_002763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | colorectal cancerous tissues, cell lines (LoVo, SW620, SW480, LS174T, HCT116 and HT29, HUVEC) |
| Expression Pattern | down-regulated |
| Function Description | Expression of CPS1-IT1 were significantly reduced, while HIF-1a and LC3-II were increased in CRC tissues and cell lines.CPS1-IT1 suppresses EMT and autophagy by inhibiting the activation of HIF-1a in CRC.lncRNA CPS1-IT might suppresses metastasis and EMT by inhibiting hypoxia induced autophagy through inactivation of HIF-1a in CRC. |
| Pubmed ID | 29017924 |
| Year | 2017 |
| Title | LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1a |
External Links
| Links for CPS1-IT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |