Basic Information
| LncRNA/CircRNA Name | CPS1-IT1 |
| Synonyms | CPS1-IT1, CPS1-IT, CPS1IT, CPS1IT1, PRO0132 |
| Region | GRCh38_2:210617571-210619876 |
| Ensemble | ENSG00000280837 |
| Refseq | NR_002763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase report assay etc. |
| Sample | EOC tissues, cell lines (A2780, CAOV-3, ES-2, HOSE) |
| Expression Pattern | down-regulated |
| Function Description | CPS1-IT1 was significantly downregulated in EOC cell lines and tissue samples.EOC patients in the low tissue CPS1-IT1 expression group had significantly shorter 5-year overall survival time than those in the high tissue CPS1-IT1 expression group.Survival analysis wasper formed using the Kaplan-Meier method and Cox?? proportional hazards model. |
| Pubmed ID | 28770969 |
| Year | 2017 |
| Title | Long non-coding RNA CPS1-IT1 is a positive prognostic factor and inhibits epithelial ovarian cancer tumorigenesis. |
External Links
| Links for CPS1-IT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |