Basic Information
| LncRNA/CircRNA Name | CPS1-IT1 |
| Synonyms | CPS1-IT1, CPS1-IT, CPS1IT, CPS1IT1, PRO0132 |
| Region | GRCh38_2:210617571-210619876 |
| Ensemble | ENSG00000280837 |
| Refseq | NR_002763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Cell transfection etc. |
| Sample | lung cancer tissues, cell lines (A549, H1975, SPC-A-1, H125, and 95D) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA CPS1-IT1 was significantly lower in cancerous tissues than in noncancerous tissues. lncRNA CPS1-IT1 was differentially expressed in lung cancer cell lines and expressed the least in two highly invasive cell lines, A549 and 95D. Overexpression of CPS1-IT1 slowed down cell proliferation by 35.7% in A549 cells and 30.8% in 95D cells on the fifth day. Cell migration was inhibited by 59% in A549 cells and 48% in 95D cells, and cell invasion was suppressed by 60% in both cell lines after overexpression of CPS1-IT1. |
| Pubmed ID | 27662619 |
| Year | 2017 |
| Title | Long Noncoding RNA CPS1-IT1 Suppresses Cell Proliferation and Metastasis in Human Lung Cancer. |
External Links
| Links for CPS1-IT1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |