Basic Information
| LncRNA/CircRNA Name | lncCMPK2 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot etc |
| Sample | CRC tissues, cell lines (HCT29, HCT116, LS174T, SW480,SW620, CACO2, DLD1, LOVO) |
| Expression Pattern | up-regulated |
| Function Description | In the present study, the expression of lncCMPK2 was upregulated in CRC tissues and positively correlated with clinical stages and lymphatic metastasis. The overexpression of lncCMPK2 promoted the proliferation and cell cycle transition of CRC cells. Conversely, the silencing of lncCMPK2 restricted cell proliferation both in vitro and in vivo. lncCMPK2 was localized to the nucleus of CRC cells, bound to far upstream element binding protein 3 (FUBP3), and guided FUBP3 to the far upstream element (FUSE) of the c-Myc gene to activate transcription. |
| Pubmed ID | 32203166 |
| Year | 2020 |
| Title | Long Noncoding RNA CMPK2 Promotes Colorectal Cancer Progression by Activating the FUBP3-c-Myc Axis |
External Links
| Links for lncCMPK2 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |