Basic Information
| LncRNA/CircRNA Name | CERS6-AS1 |
| Synonyms | ceramide synthase 6 antisense RNA 1 |
| Region | GRCh38_2:168771953-168786961 |
| Ensemble | ENSG00000227617 |
| Refseq | NR_045786 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blotting, RIP |
| Sample | BC tissues,BC cells (MDA-MB-436, MDA-MB-453, MCF-7 and MDA-MB-231) and normal human breast cell (MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | CERS6-AS1 was overexpressed in BC tissues and cells. CERS6-AS1 accelerated cell proliferation and suppressed cell apoptosis in BC.IGF2BP3 serves as a RNA-binding protein for CERS6-AS1 and CERS6-AS1 promoted CERS6 mRNA stability by binding to IGF2BP3. |
| Pubmed ID | 31701672 |
| Year | 2020 |
| Title | Long Noncoding RNA CERS6-AS1 Functions as a Malignancy Promoter in Breast Cancer by Binding to IGF2BP3 to Enhance the Stability of CERS6 mRNA |
External Links
| Links for CERS6-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |