Basic Information
| LncRNA/CircRNA Name | ADAMTS9-AS2 |
| Synonyms | lncADAMTS9-AS2 |
| Region | GRCh38_3:64684909-65011468 |
| Ensemble | ENSG00000241684 |
| Refseq | NR_038264 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | qPCR, Microarray, Western blot |
| Sample | TSCC tissues,TSCC cell lines (Cal27, SCC9, SCC15, SCC25 and SCC4) |
| Expression Pattern | up-regulated |
| Function Description | demonstrated that ADAMTS9-AS2 is the most upregulated lncRNA in lymph node metastatic TSCC tissues, indicating that it has an important effect on TSCC metastasis. Importantly, we show that ADAMTS9-AS2 perform its biological function via sponging miR-600 and enhancing the expression of enhancer of zeste homolog 2 (EZH2). |
| Pubmed ID | 30970517 |
| Year | 2019 |
| Title | LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis. |
External Links
| Links for ADAMTS9-AS2 | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |