Basic Information
LncRNA/CircRNA Name | CDKN2B-AS1 |
Synonyms | NA |
Region | GRCh38_9:21994778-22121097 |
Ensemble | ENSG00000240498 |
Refseq | NR_003529 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | osteosarcoma |
ICD-0-3 | NA |
Methods | RT-qPCR, Western blot analysis, RIP, Luciferase reporter analysis |
Sample | OS tissues,osteoblast (hFOB) and OS cells (U2OS, Saos-2, MG-63, and SW1353) |
Expression Pattern | up-regulated |
Function Description | CDKN2B-AS1 expression were remarkably upregulated in OS tissues and cells. Moreover, CDKN2B-AS1 knockdown suppressed cell proliferation, migration, and EMT progress in OS.MAP3K3 was negatively regulated by miR-4458 and positively regulated by CDKN2B-AS1. |
Pubmed ID | 31950433 |
Year | 2020 |
Title | Long Non-Coding RNA CDKN2B-AS1 Promotes Osteosarcoma by Increasing the Expression of MAP3K3 via Sponging miR-4458 |
External Links
Links for CDKN2B-AS1 | GenBank HGNC NONCODE |
Links for osteosarcoma | OMIM COSMIC |