Basic Information
| LncRNA/CircRNA Name | CDKN2B-AS1 |
| Synonyms | NA |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | LSCC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | The expression of CDKN2B-AS1 was significantly higher in LSCC tissues than in adjacent normal tissues.The observations in this study identify CDKN2B-AS1 an oncogenic role in the tumorigenesis of LSCC by regulating miR-497/CDK6 axis and indicate that it may serve as a potential target for LSCC treatment. |
| Pubmed ID | 31754305 |
| Year | 2019 |
| Title | Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway |
External Links
| Links for CDKN2B-AS1 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |