Basic Information
| LncRNA/CircRNA Name | CDKN2B-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Gemcitabine | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder urothelial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | bladder urothelial cancer tissues, cell lines (SV-HUC-1 and BUC) |
| Expression Pattern | up-regulated |
| Function Description | CDKN2B-AS gene was high-expressed in BUC tissues and J82, T24 cells compared with paracancerous normal urothelial tissues and SV-HUC-1 cells. Furthermore, the high-expression of CDKN2B-AS gene was related with high pathological grade and low Gemcitabine sensitivity of BUC tissues. The expression of CDKN2B-AS gene in Gemcitabine-resistant T24/Gem cells was much higher than that in T24 cells. Moreover, under treating with Gemcitabine, knockdown of CDKN2B-AS depressed cell viability of T24/Gem cells , and promoted apoptosis of T24/Gem cells. Knockdown of CDKN2B-AS gene sensitized T24/Gem cells to Gemcitabine, promoted Gemcitabine-induced cytotoxicity. Knockdown of CDKN2B-AS gene inactivated Wnt signaling pathway, and Wnt signaling pathway mediated the effects on Gemcitabine sensitivity induced by CDKN2B-AS knockdown in T24/Gem cells. |
| Pubmed ID | 29937935 |
| Year | 2018 |
| Title | Long Non-Coding RNA CDKN2B Antisense RNA 1 Gene Inhibits Gemcitabine Sensitivity in Bladder Urothelial Carcinoma |
External Links
| Links for CDKN2B-AS | GenBank HGNC NONCODE |
| Links for bladder urothelial cancer | OMIM COSMIC |