Basic Information
| LncRNA/CircRNA Name | CDC6 |
| Synonyms | CDC18L, HsCDC18, HsCDC6, MGORS5 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assays, RIP, other |
| Sample | BC tissues and cell lines (MCF-10A, MCF-10AT, MCF-10CA1A, and MCF-10CA1H cell lines) |
| Expression Pattern | up-regulated |
| Function Description | Functionally, the ectopic expression of lncRNA-CDC6 promoted proliferation via regulation of G1 phase checkpoint, and further promoting the migration capability. Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which further regulating the expression of CDC6. Taken together, our results proved that lncRNA-CDC6 could function as ceRNA and promote the proliferation and metastasis of breast cancer cells, which provided a novel prognostic marker for breast cancers in clinic. |
| Pubmed ID | 30362551 |
| Year | 2019 |
| Title | LncRNA-CDC6 Promotes Breast Cancer Progression and Function as ceRNA to Target CDC6 by Sponging microRNA-215 |
External Links
| Links for CDC6 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |