Basic Information
| LncRNA/CircRNA Name | CCND2-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:4248765-4276184 |
| Ensemble | ENSG00000255920 |
| Refseq | NR_125790 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | human thyroid cancer cell lines (TPC1 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | CCND2-AS1 expression was significantly over-expressed in PTC cell lines compared to normal thyroid epithelial cells. Gain-and loss-of-function experiments were performed to investigate the role of CCND2-AS1 in PTC cells. In vitro experiments, we proved that CCND2-AS1 knockdown in TPC1 significantly suppressed cell proliferation, migration, and invasion, while CCND2-AS1 overexpression in BCPAP had the opposite effects. Meanwhile, we also found that CCND2-AS1 could regulate N-cadherin and Vimentin expression, which may influence invasion and migration. |
| Pubmed ID | 29366479 |
| Year | 2018 |
| Title | LncRNA CCND2-AS1 promotes proliferation, migration, and invasion in papillary thyroid carcinoma. |
External Links
| Links for CCND2-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |