Basic Information
| LncRNA/CircRNA Name | CCHE1 |
| Synonyms | CCEPR, CCHE1, lncRNA-CCHE1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_131782 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Western blot, RNA pull-down assay etc. |
| Sample | cervical cancer tissues, cell lines (HeLa, SiHa) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that cervical carcinoma high-expressed lncRNA 1 (lncRNA-CCHE1) was significantly upregulated in cervical cancer tissues. The higher expression of CCHE1 was significantly correlated with large tumor size, advanced Federation of Gynecology and Obstetrics stage, uterine corpus invasion, and poor survival. CCHE1 plays a pivotal role in cervical cancer cell proliferation via increasing PCNA expression and serves as a potential prognostic biomarker and therapeutic target in human cervical cancer. |
| Pubmed ID | 25921283 |
| Year | 2015 |
| Title | Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA. |
External Links
| Links for CCHE1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |