Basic Information
| LncRNA/CircRNA Name | CCHE1 |
| Synonyms | CCEPR, CCHE1, lncRNA-CCHE1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_131782 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Flow cytometry assay, MTT assay etc. |
| Sample | HCC tissues, cell lines (MHCC97H, Huh-7, Hep3B, HepG2 and HCCLM3) |
| Expression Pattern | up-regulated |
| Function Description | The level of CCHE1 expressed in all five HCC cell lines was significantly higher than the normal hepatocyte L02 cells. The higher expression of CCHE1 was significantly correlated with tumor number, tumor size and TNM stage. Multivariate analyses revealed that CCHE1 expression served as an independent predictor for overall survival. Moreover, the effect of CCHE1 on proliferation was evaluated by MTT assays, and cell apoptosis was detected by flow-cytometric analysis. Further experiments demonstrated that CCHE1 knockdown significantly promoted growth arrest and cell apoptosis. Importantly, we further confirmed that ERK/MAPK pathway was found to be inactivated in the HCC cells after CCHE1 knockdown. |
| Pubmed ID | 27427851 |
| Year | 2016 |
| Title | Long noncoding RNA CCHE1 indicates a poor prognosis of hepatocellular carcinoma and promotes carcinogenesis via activation of the ERK/MAPK pathway. |
External Links
| Links for CCHE1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |