Basic Information
| LncRNA/CircRNA Name | CCHE1 |
| Synonyms | CCEPR, CCHE1, lncRNA-CCHE1 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_131782 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | pancreatic adenocarcinoma cell lines Capan-2, HPAF-II, serum |
| Expression Pattern | up-regulated |
| Function Description | CCHE1 overexpression distinguished patients with metastatic pancreatic adenocarcinoma from patients with non-metastatic pancreatic adenocarcinoma and healthy controls. A significant positive correlation between serum levels of CCHE1 and ROCK1 was identified in patients with metastatic pancreatic adenocarcinoma. Furthermore, CCHE1 overexpression led to upregulated ROCK1 in human pancreatic adenocarcinoma cell lines, whereas no significant effects of ROCK1 overexpression upon CCHE1 expression were identified. CCHE1 overexpression promoted the migration and invasion of human pancreatic adenocarcinoma cell lines, but no significant effects on cell proliferation were identified. ROCK1 small interfering RNA-induced silencing partially reversed the enhancing effects of CCHE1 overexpression on cancer cell migration and invasion. |
| Pubmed ID | 31423182 |
| Year | 2019 |
| Title | lncRNA-CCHE1 Is Involved in Migration and Invasion but Not in Proliferation of Pancreatic Adenocarcinoma Cells Possibly by Interacting With ROCK1 |
External Links
| Links for CCHE1 | GenBank HGNC NONCODE |
| Links for pancreatic adenocarcinoma | OMIM COSMIC |