Basic Information
| LncRNA/CircRNA Name | CCEPR |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_131782 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | colorectal cancer tissues and paired adjacent normal tissues,human colorectal cancer cell lines(HT29, Caco2, SW480 and LS174T) and the normal human intestinal epithelial cell line, HIEC |
| Expression Pattern | up-regulated |
| Function Description | CCEPR expression was significantly higher in colorectal cancer tissues when compared with paired adjacent normal tissues.High CCEPR expression was significantly associated with poor differentiation, advanced clinical stage, positive lymph node metastasis and distant metastasis.Patients with colorectal cancer exhibiting high CCEPR expression levels had shorter survival rates when compared with patients with low CCEPR expression.The expression of CCEPR was increased in colorectal cancer cell lines when compared with a normal colon cell line. Knockdown of CCEPR significantly inhibited colorectal cancer cell proliferation, colony formation and cell cycle progression, as well as cell migration and invasion.Finally, silencing of CCEPR downregulated matrix metalloproteinase (MMP)-2 and MMP-9 expression and suppressed epithelial-mesenchymal transition in colorectal cancer cells. |
| Pubmed ID | 31602230 |
| Year | 2019 |
| Title | Knockdown of lncRNA CCEPR Suppresses Colorectal Cancer Progression |
External Links
| Links for CCEPR | GenBank HGNC NONCODE |
| Links for colorectal adenocarcinoma | OMIM COSMIC |