Basic Information
| LncRNA/CircRNA Name | CCDC26 |
| Synonyms | CCDC26, RAM |
| Region | GRCh38_8:128634199-129683679 |
| Ensemble | ENSG00000229140 |
| Refseq | NR_130917 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | cell lines (HL-60, K562 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We found that CCDC26 transcripts were abundant in the nuclear fraction of K562 human myeloid leukemia cells. We suggest that CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression.A KIT inhibitor might be an effective treatment against the forms of AML in which CCDC26 is altered. |
| Pubmed ID | 25928165 |
| Year | 2015 |
| Title | Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. |
External Links
| Links for CCDC26 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |