Basic Information
| LncRNA/CircRNA Name | CCAT5 |
| Synonyms | NA |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | CRC tissues and adjacent tissues ,human CRC cell lines (HCT116, HT29, SW620, and SW480) and normal human colonic epithelial cell line (NCM460) |
| Expression Pattern | up-regulated |
| Function Description | By comparison with CCAT5 expression in adjacent tissues, the CCAT5 expression level was significantly higher in CRC samples. Moreover, after CCAT5 was downregulated, cell migration and cell invasion of CRC cells were suppressed. Besides, after knockdown of CCAT5, the mRNA and protein expression of STAT3 was repressed. Furthermore, it was found that STAT3 expression was positively correlated to CCAT5 expression in CRC tissues. |
| Pubmed ID | 31599415 |
| Year | 2019 |
| Title | Downregulating Long Non-Coding RNA CCAT5 Inhibits Tumor Growth, Invasion and Metastasis in Colorectal Cancer Through Suppressing STAT3 |
External Links
| Links for CCAT5 | GenBank HGNC NONCODE |
| Links for colorectal adenocarcinoma | OMIM COSMIC |