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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc.
Sample	HCC tissue, HCC cell lines including HepG2, Hep3B, HCCLM3, and MHCC97H
Expression Pattern	down-regulated
Function Description	Further analyses confirmed that A1BG AS1 expression in HCC was markedly lower than that in noncancerous tissues based on our HCC cohort. Clinical association analysis revealed that low A1BG AS1 expression correlated with poor prognostic features, such as microvascular invasion, high tumor grade, and advanced tumor stage. Follow up data indicated that low A1BG AS1 level evidently correlated with poor clinical outcomes of HCC patients. Moreover, forced expression of A1BG AS1 repressed proliferation, migration, and invasion of HCC cells in vitro. Conversely, A1BG AS1 knockdown promoted these malignant behaviors in HepG2 cells. Mechanistically, A1BG AS1 functioned as a competing endogenous RNA by directly sponging miR 216a 5p in HCC cells. Notably, miR 216a 5p restoration rescued A1BG AS1 attenuated proliferation, migration and invasion of HCCLM3 cells. A1BG AS1 positively regulated the levels of phosphatase and tensin homolog and SMAD family member 7, which were reduced by miR 216a 5p in HCC cells.
Pubmed ID	30556161
Year	2018
Title	lncRNA A1BG-AS1 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells by Targeting miR-216a-5p

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