Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | glioma tissues, cell lines (A172, U87-MG, U251, and T98G) |
| Expression Pattern | up-regulated |
| Function Description | Downregulation of linc-CCAT2 revealed the opposite effect. glioma cells could promote angiogenesis through the transfer of linc-CCAT2 by exosomes to endothelial cells.For example, Skog et al (18) reported that glioma cell-derived exosomes contained mRNA, miRNA and angiogenic proteins, which can be taken up by brain microvascular endothelial cells and stimulate tubule formation and angiogenesis. |
| Pubmed ID | 28656228 |
| Year | 2017 |
| Title | Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2. |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |