Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase report assay, RIP, ChIP etc. |
| Sample | HCC tissues, cell lines (SMMC-7721, PLC/PRF/5, Huh7, SK-Hep-1, and Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | a significant upregulation of CCAT2 in HCC tissues as compared to non-tumor tissues. CCAT2 functions as a competitive endogenous RNA (ceRNA) of FOXM1 through competitive interaction with miR-34a. a positive correlation between the tumorous CCAT2 expression and a significantly reduced overall survival (OS) (P<0.001). |
| Pubmed ID | 28744394 |
| Year | 2017 |
| Title | A positive feedback loop of long noncoding RNA CCAT2 and FOXM0 promotes hepatocellular carcinoma growth. |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |