Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | EOC cell lines (SKOV3, A2780,HO8910, HOSE HUM-CELL-0088) |
| Expression Pattern | up-regulated |
| Function Description | Functional assays demonstrated that the knockdown of CCAT2 inhibited migration and invasion of EOC cells in vitro. Moreover, our results showed that silencing CCAT2 inhibited EMT by the upregulation of epithelial cadherin and downregulation of neural cadherin, zinc finger protein SNAI and Twist-related protein 1 in SKOV3 and A2780 cell lines.knockdown of CCAT2 inhibited the expression of B -catenin and the activity of T-cell factor/lymphoid enhancer factor, acting as a key transcription factor of Wnt signaling pathway. Collectively, these results indicate that CCAT2 may promote EMT, at least partly through Wnt/ B -catenin signaling pathway in EOC cells. |
| Pubmed ID | 29435081 |
| Year | 2017 |
| Title | Long non-coding RNA CCAT2 promotes epithelial-mesenchymal transition involving Wnt/B-catenin pathway in epithelial ovarian carcinoma cells. |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |