Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR etc. |
| Sample | cell line (Tca8113) |
| Expression Pattern | up-regulated |
| Function Description | RT-qPCR showed that the expression of CCAT2 was significantly higher in OSCC than that in adjacent tissues. High CCAT2 expression was associated with cell differentiation and pathological stage of OSCC. CCAT2 expression in low-differentiated OSCC was significantly higher than that in high-differentiated cancer. In addition, CCAT2 level in stage 3/4 OSCC was significantly higher than that in stage 1/2 cancer. Furthermore, inhibition of CCAT2 expression suppressed the proliferation of human tongue carcinoma Tca8113 cells. |
| Pubmed ID | 27220388 |
| Year | 2016 |
| Title | Expression of long non-coding RNA colon cancer associated transcript 2 and its clinicopathologic significance in oral squamous cell carcinoma |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |