Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | NA |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | lung adenocarcinoma cells (A549, SPC-A-1, H1395, H441, and H1975 cell lines) and human normal lung epithelial cell line (BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | The expression of CCAT2 was upregulated obviously in lung adenocarcinoma cells. Cell function analysis showed that upregulation of CCAT2 significantly promoted cell proliferation and migration, and reduction of CCAT2 inhibited cell migration and proliferation. In addition, CCAT2 positively regulated the expression of FOXC1 by competitive binding with miR 23b 5p. These findings indicated that CCAT2 may act as a competitive endogenous RNA (ceRNA) to regulate FOXC1 expression by competitively binding miR 23b 5p in lung adenocarcinoma. |
| Pubmed ID | 30548656 |
| Year | 2018 |
| Title | Long noncoding RNA CCAT2 functions as a competitive endogenous RNA to regulate FOXC1 expression by sponging miR-23b-5p in lung adenocarcinoma |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |