Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot, other |
| Sample | esophageal cancer cell lines (KYSE150, Eca-109, EC9706, TE-1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of CCAT2 was significantly decreased in si-CCAT2 Eca-109 cells. Treatment with si-CCAT2 and FH535 alone or in combination significantly inhibited the proliferation, migration and invasion of Eca-109 cells. The treatments also promoted apoptosis, upregulated the expression of Bax and APC proteins, and downregulated ?-catenin, PCNA, cyclin D1 and c-Myc proteins. In summary, lncRNA CCAT2 is upregulated in esophageal cancer cells and the knockdown of lncRNA CCAT2 inhibits the |
| Pubmed ID | 31423241 |
| Year | 2019 |
| Title | Long Non-Coding RNA Colon Cancer-Associated Transcript 2 May Promote Esophageal Cancer Growth and Metastasis by Regulating the Wnt Signaling Pathway |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |