Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | NA |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-PCR, Western blot assay |
| Sample | breast tumor samples,breast cancer cell line MDA-MB-231, MCF-7, T-47D, MDA-MB-231 and Hs578t |
| Expression Pattern | up-regulated |
| Function Description | CCAT2 overexpressed specially in TNBC, and in breast cancer stem cells (BCSC) as well.CCAT2 promoted the expression of stemness markers including OCT4, Nanog and KLF4, increased mammosphere formation and induced ALDH+ cancer stem cell population in TNBC. |
| Pubmed ID | 31904506 |
| Year | 2020 |
| Title | Long Non-Coding RNA CCAT2 Promotes Oncogenesis in Triple-Negative Breast Cancer by Regulating Stemness of Cancer Cells |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |