Basic Information
| LncRNA/CircRNA Name | CCAT2 |
| Synonyms | NA |
| Region | GRCh38_8:127400399-127402150 |
| Ensemble | ENSG00000280997 |
| Refseq | NR_109834 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | Western blot etc. |
| Sample | cell lines (SKOV3 and A2780 ) |
| Expression Pattern | up-regulated |
| Function Description | CCAT2 and MYC Genes are Overexpressed in Ovarian Cancer.Here, we foundd that calcitriol inhibited CCAT2 expression in ovarian cancer cell lines. Treatment with calcitriol inhibited ovarian cancer cell proliferation, migration, and invasion. As a result of CCAT2 inhibition, calcitriol decreased the binding of transcription factor TCF7L2 (TCF4) to the MYC promoter, resulting in the repression of c-Myc protein expression. |
| Pubmed ID | 32230936 |
| Year | 2020 |
| Title | Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2 |
External Links
| Links for CCAT2 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |