Basic Information
| LncRNA/CircRNA Name | CCAT1-L |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric adenocarcinoma |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, other |
| Sample | gastric adenocarcinoma tissues and cell lines (MGC803, MKN-28,SGC7901, and BGC823) |
| Expression Pattern | up-regulated |
| Function Description | There was a positive correlation between the expression level of CCAT1-L mRNA and c-MYC mRNA . CCAT1-L expression was also significantly higher in gastric adenocarcinoma cell lines than that in normal cell lines . Knockdown of CCAT1-L in MGC803 and MKN-28 cells markedly reduced the cell proliferation, migration, and invasion. CCAT1-L knockdown also evidently inhibited tumor growth and improved survival in nude mice. Expressions of MYC, RAS, and vimentin, and the phosphorylation of ERK protein were dramatically decreased, while the expression of E-cadherin protein was increased by CCAT1-L knockdown in MKN-28 cell. |
| Pubmed ID | 30254457 |
| Year | 2018 |
| Title | Upregulation of Long Noncoding RNA CCAT1-L Promotes Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma |
External Links
| Links for CCAT1-L | GenBank HGNC NONCODE |
| Links for gastric adenocarcinoma | OMIM COSMIC |