Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | lung cancer cell lines (H358, H23, H1975, H1650, H1299 and A549) and a normal human bronchial epithelial cell line (16HBE), Lung adenocarcinoma tissues and pair-matched adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression of CCAT1 was identified to be increased in lung adenocarcinoma tissues and its expression level was associated with epidermal growth factor receptor (EGFR) expression (P=0.011), lymphatic metastasis (P=0.003) and tumor node metastasis (TNM) stage (P=0.003).aberrant CCAT1 expression may induce epithelial-to-mesenchymal transition (EMT) by regulating the expression levels of EMT markers (E-cadherin, N-cadherin and vimentin). |
| Pubmed ID | 30008869 |
| Year | 2018 |
| Title | Overexpression of the long noncoding RNA CCAT1 promotes metastasis via epithelial-to-mesenchymal transition in lung adenocarcinoma. |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |