Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qRT-PCR, ect. |
| Sample | The human NPC cell lines (SUNE-1 and C666-1) and human nasopharyngeal epithelial cell line (NP69),nasopharyngeal carcinoma tissues normal nasopharyngeal epithelial tissues |
| Expression Pattern | up-regulated |
| Function Description | The function of CCAT1 in the proliferation, migration, invasion and apoptosis of NPC cells was detected by MTT, cell scratch, Transwell, flow cytometry and caspase-3 ELISA assays, respectively.the expression levels of CCAT1 were significantly upregulated in NPC tissues compared with normal nasopharyngeal epithelial tissues.Furthermore, the knockdown of CCAT1 was indicated to inhibit growth, migration and invasion, and induce apoptosis in NPC cells. |
| Pubmed ID | 30013670 |
| Year | 2018 |
| Title | Identification of long non-coding RNA CCAT1 as an oncogene in nasopharyngeal carcinoma. |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |