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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qPCR etc.
Sample	CRC tissues
Expression Pattern	down-regulated
Function Description	we found that the levels of HOTAIR and CCAT1 were significantly higher in plasma of CRC patients than that of the healthy control. Moreover, the levels of lincRNA-p21 were obviously decreased in plasma of CRC patients as compared to those of healthy control. There was highly correlated for CCAT1, HOTAIR and lincRNA-p21 in plasma and serum. By receiver operating characteristic curve (ROC) analysis, plasma CCAT1 provided the higher diagnostic performance for detection of CRC. Moreover, CCAT1 combining with HOTAIR could provide a more effective diagnosis performance. Most importantly, this combination was effective to detect CRC at an early stage (85%). In conclusion, our results demonstrated that increased plasma HOTAIR and CCAT1 could be used as a predictive biomarker for CRC screening, and that combination of HOTAIR and CCAT1 had a higher positive diagnostic rate of CRC than HOTAIR or CCAT1 alone
Pubmed ID	26823726
Year	2016
Title	Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma

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