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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	esophageal cancer
ICD-0-3	C15
Methods	PCR
Sample	Human esophageal squamous cancer cell lines KYSE-150, Radioresistant cell line KYSE150R
Expression Pattern	up-regulated
Function Description	To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs, Among the detected candidate 3752 circRNA genes, significant upregulation of 57 circRNAs and downregulation of 17 circRNAs in human radioresistant esophageal cancer cell line KYSE-150R were observed compared with the parental cell line KYSE-150 (fold change >=2.0 and P < 0.05). There were 9 out of these candidate circRNAs were validated by real-time PCR. GO analysis revealed that numerous target genes, including most microRNAs were involved in the biological processes. There were more than 400 target genes enrichment on Wnt signaling pathway. CircRNA_001059 and circRNA_000167 were the two largest nodes in circRNA/microRNA co-expression network.
Pubmed ID	27465405
Year	2017
Title	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells

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