Basic Information
| LncRNA/CircRNA Name | circBANP |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-PCR, In situ hybridization, RNA interference, CCK-8, Colony formation assay, Western blot assay |
| Sample | CRC cancerous and adjacent normal tissues, HCT116 and HT29 cells |
| Expression Pattern | up-regulated |
| Function Description | we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated circRNAs in CRC cancerous tissues (>2-fold changes). We further validated one circRNA generated from Exon 5-11 of BANP gene, termed circ-BANP. In addition, RT-PCR result showed that circ-BANP was overexpressed in 35 CRC cancerous tissues. Knockdown of circ-BANP with siRNA significantly attenuate the proliferation of CRC cells. |
| Pubmed ID | 28103507 |
| Year | 2017 |
| Title | Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer |
External Links
| Links for circBANP | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |