Basic Information
| LncRNA/CircRNA Name | circ_0000190 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Reverse transcription, qRT-PCR |
| Sample | gastric cancer tissues and adjacent normal tissues, blood |
| Expression Pattern | down-regulated |
| Function Description | Hsa_circ_0000190 was first found to be down-regulated in gastric cancer tissues (P b 0.001) and plasma samples from patients with gastric cancer (P b 0.001). Its expression levels were significantly correlated with tumor diameter (P = 0.034), lymphatic metastasis (P = 0.026), distal metastasis (P = 0.001), TNM stage (P = 0.001), and CA19-9 levels (P = 0.019). The areas under the ROC curve (AUC) of hsa_circ_0000190 in tissues and plasma were up to 0.75 and 0.60, respectively. The sensitivity and specificity of the combination were 0.712 and 0.750; the AUC was increased to 0.775. |
| Pubmed ID | 28130019 |
| Year | 2017 |
| Title | Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer |
External Links
| Links for circ_0000190 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |